Sildenafil - ka hana, nā hōʻailona, ​​nā contraindications, nā hopena ʻaoʻao

ʻO Sildenafil kahi lāʻau i hoʻohana ʻia e mālama i ka erectile dysfunction. Ua kuhikuhi mua ʻia i nā poʻe maʻi me ka hypertension pulmonary, akā ua ʻike koke ʻia kona hopena i ka moekolohe. I kēia manawa he lāʻau lapaʻau i ʻōlelo pinepine ʻia no nā kāne e hakakā nei me ka pilikia o ka impotence. He aha kāu e ʻike ai e pili ana iā Sildenafil?

1. He aha ka Sildenafil?

ʻO nā lāʻau lapaʻau nui no ka mālama ʻana i ka erectile dysfunction he phosphodiesterase type 5 inhibitors (PDE-XNUMX). ʻO ka lāʻau kaulana loa o kēia ʻano ʻo Viagra.

Ua hoʻokomo mua ʻia i ka makahiki 1998 i ka mākeke US a mai ia manawa ua loaʻa ma kahi kokoke i nā wahi āpau o ka honua. Eia naʻe, pono e hoʻomanaʻo ʻia he nui nā lāʻau lapaʻau me ka hana like o ka hana. ʻO ka mea kaulana loa:

• ʻO Sildenafil
• tadalafil,
• ʻO Vardenafil.

ʻO ka hoʻokomoʻana o Sildenafil a me ka laulā o nā lāʻau lapaʻau mai kēia hui he mea maʻamau. I ka wā mua, ua kuhikuhi ʻia ʻo sildenafil i nā poʻe maʻi me ka hypertension arterial pulmonary. ʻO kāna hopena hoʻonui kūkulu uaʻike kokeʻia e nā maʻi, kahi i hoʻololi i nā hōʻailona no ka hoʻohanaʻana i kēia lāʻau.

Ma mua o ka wā o ka sildenafil, hoʻohana nā kāne a hoʻohana pinepine i nā mea ʻē aʻe he nui, ka mea i kapa ʻia he poʻe, kikoʻī. He palekana ka ʻōlelo ʻana aia i kēlā me kēia moʻomeheu kekahi mea e hoʻomaikaʻi i ka potency. A ʻae, ua hoʻohana ka poʻe i kēia mau lāʻau lapaʻau no ka erectile dysfunction no nā kenekulia:

• Ua kaulana loa ka pauka horn rhino ma Kina,
• ma nā moʻomeheu ʻē aʻe, he koko ia o ka ʻōpeʻapeʻa, ka ʻāʻī o ka alopeke a me ka dia, ka lolo o ka pōpoki,
• wormwood, verbena, ginger, kālika, lovage, nutmeg, cloves.

Pono e hoʻomaopopo ʻia ʻaʻole i loaʻa i ka hapa nui o kēia mau mea i kahi ʻano hana i hōʻoia ʻia. Hoʻokumu wale ʻia kā lākou hana ma luna o ka manaʻo kilokilo i kā lākou hana.

2. Pehea e hana ai ʻo Sildenafil

Ua hoʻopaʻa mua ʻia ʻo Sildenafil ma 1996 a paʻi i ka mākeke i ʻelua makahiki ma hope. I kēia manawa, he lāʻau ia no ka potency, me ka hypertension pulmonary mua (III functional class) a me kekahi mau maʻi o ka ʻiʻo pili.

Aia nā lāʻau lapaʻau i ka 25-100 milligrams o ka sildenafil citrate. Aia ʻo Sildenafil i loko o kona ʻano he piperazine motif a me kahi analog guanine, 1H-pyrazolo [4,3-d] pyrimidine. ʻO ka ʻōnaehana phenol kikowaena ka mea like me ka ribose, a ʻo ke koena sulfone pili i ka pūʻulu phosphate o ka nucleotide.

ʻO kēia pūhui i loko o ke kino ke kāohi nei i ka phosphodiesterase type 5 (PDE5) - ʻoi aku ka haʻahaʻa o ka pilina no nā ʻano ʻē aʻe o kēia enzyme. Hoʻopau ʻo PDE5 i ka cGMP, ʻo ia ke kuleana no ka hoʻomaha ʻana o ka ʻiʻo maʻemaʻe a me ka hoʻonui ʻana i ke kahe koko i nā kino cavernous.

I ka wā o ka hoʻoulu ʻana i ka wahine, hoʻomaka nā pūnaewele nerve e hana i ka nitric oxide (NO), kahi e hiki ai ke hoʻohana i ka cGMP. Hoʻopaʻa ʻia e sildenafil, PDE5 hiki iā ʻoe ke "mālama" i kahi kūkulu.

Eia nō naʻe, i loko o nā kāne he nui, ma muli o ka neurosis, ke kaumaha o ka noʻonoʻo, ke ʻano o ka hormonal imbalance a i ʻole nā ​​​​maʻi o ka ʻōnaehana nerve sympathetic, ʻoi aku ka nāwaliwali o ka hana ʻana o ka nitric oxide e nā pūnana nerve, kahi e alakaʻi ai i ka nāwaliwali a pōkole loa. Loaʻa ka wikiwiki wikiwiki loa ma hope o ka lawe ʻana i ka lāʻau ma ka ʻōpū ʻole. Hoʻokuʻu ʻia ia me nā faeces (ma kahi o 80%) a i kahi liʻiliʻi me ka mimi.

3. Nā hōʻailona no ka hoʻohanaʻana iā Sildenafil

He ʻumi lāʻau no ka ikaika hiki i nā kāne ke hoʻokō i kahi kūkulu mau a loaʻa i ka moekolohe. ʻO ka maikaʻi o kēia lāʻau lapaʻau ʻo ka ʻoiaʻiʻo ʻaʻole hiki ke kūkulu koke ʻia ma hope o ka lawe ʻana i ka pill, akā koi ʻia ka hoʻoulu ʻana i ka wahine (ʻaʻole like me nā lāʻau prostaglandin).

Manaʻo ʻia ka lāʻau lapaʻau e lawe i hoʻokahi a ʻeono mau hola ma mua o ka hoʻolālā ʻana i ka moe. Ma hope o ka loiloi ʻana o ke kauka i ke ʻano a me ke ʻano o ka impotence, koho ke kauka i ke ʻano o ka lāʻau (25, 50 a i ʻole 100 mg), e hiki ai iā ʻoe ke mālama i ke kūkulu ʻana mai 30 mau minuke i hoʻokahi hola. Manaʻo ʻia ka lāʻau e lawe i hoʻokahi manawa i ka lā. No ka poʻe me ka lawa ʻole o ka renal koʻikoʻi, ʻōlelo ʻia ka hoʻemi ʻana i ka nui.

4. Contraindications

ʻAʻole pono e lawe ʻia kēia lāʻau e nā kāne ma lalo o kēia mau kūlana:

• maʻi ʻaʻaʻa coronary,
• ka maʻi hypertension malignant,
• ka hāʻule ʻole o ke kahe (NYHA class III a me IV),
• me ka hōʻeha puʻuwai hou (ʻelua pule mua),
• ʻo ka maʻi cardiomyopathy
• me nā ventricular arrhythmias (malignant, ma muli o ka hoʻoikaika kino, ke kaumaha, nā manaʻo),
• me ka ma'i valvular ko'iko'i
• hōʻino ʻole o ka ate a me ka puʻupaʻa,
• ma hope o ka hahau ʻana
• me nā loli degenerative i ka retina (no ka laʻana, retinitis pigmentosa),
• manaʻo hoʻohālikelike,
• me ka hypersensitivity i nā mea o ka lāʻau.

Siledenafil He hopena vasodilatory ia a hiki ke pilikia i ka poʻe e lawe ana i nā lāʻau lapaʻau cardiovascular a me vascular. ʻO kahi contraindication paʻa loa i ka lawe ʻana i ka lāʻau lapaʻau ʻo ka lawe ʻana i ka Nitrate a me Molsidomine.

Pono e noʻonoʻo ʻia nā ʻokoʻa o ka metabolism o kēia lāʻau. Ua haki ʻia i loko o ke akepaʻa, ʻo ia hoʻi ua hoʻemi ʻia ka excretion o kēia lāʻau lapaʻau i nā poʻe me nā ate poino a ʻoi aku ma mua o 65 mau makahiki, a ʻoi aku ka pōʻino o ka nui. ʻO nā lāʻau lapaʻau i ʻike ʻia e pili pū me ka siledenafil:

• hoʻohuihui,
• erythromycin,
• ketoconazole,
• rifampicin a me na mea e ae.

ʻO Sildenafil, ma muli o ka hana vasodilating, hoʻohaʻahaʻa i ke koko. I kēia lā, ua loaʻa nā make ma muli o ka hoʻohana ʻana i ka sildenafil i nā poʻe e lawe ana i nā lāʻau lapaʻau cardiovascular, e like me, no ka laʻana, nitrates a i ʻole nā ​​​​mea ʻē aʻe. nā lāʻau e hoʻohaʻahaʻa i ke koko.

ʻAʻole ʻōlelo ʻia kēia lāʻau lapaʻau no ka hoʻohana ʻana i ka impotence i nā kāne ma lalo o 18 mau makahiki a me nā hemahema anatomical o ka penis (e like me ka piko, cavernous fibrosis a i ʻole ka maʻi o Peyronie) ma hope. penile prosthesis a me nā kūlana e hoʻomaka mua iā lākou i ka priapism (e laʻa, sickle cell anemia, multiple myeloma, a i ʻole leukemia). ʻAʻole hoʻohana ʻia ka lāʻau lapaʻau ma ke ʻano he hui hui no ka mālama ʻana i ka erectile dysfunction.

5. Nā hopena ma hope o ka lawe ʻana i ka sildenafil

ʻO Sildenafil kahi lāʻau lapaʻau i ʻae ʻia e ka hapa nui o nā kāne. Hiki nō naʻe nā hopena ʻaoʻao o ka sildenafil, Pākuʻi ʻia kēia mau mea:

• poʻo a me ka noʻonoʻo
• ʻulaʻula o ka maka
• dyspepsia (nā maʻi ʻōpū),
• ʻike makapō).

ʻO nā hopena liʻiliʻi maʻamau o ka lawe ʻana i ka siledenafil:

• ka pehu o ka mucosa nasal,
• nā maʻi o ka ʻōpū a me ka urethra,
• ʻiʻo a me ka ʻeha hui.

ʻO nā hopena ʻaoʻao o ka sildenafil i hōʻike ʻia ma kahi o 35 pakeneka. Nā maʻi. ʻO ka hiʻohiʻona o kēia mau hōʻailona e pili ana me ka pale ʻana i ka PDE type 5, a me nā ʻano ʻē aʻe i loko o kekahi mau kino. Hiki i nā poʻe me ka puʻuwai puʻuwai ʻino, ke koko kiʻekiʻe, a me ke ʻano o ka loaʻa ʻana o ka puʻuwai puʻuwai hiki ke loaʻa i nā pilikia koʻikoʻi, e like me ka myocardial infarction a me ka make (ma muli o ka hoʻokuʻu ʻana o ka nitric oxide).

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau e nā kāne olakino hiki ke hoʻopilikia hou i ka hoʻokō ʻana i ke kūkulu ʻana (me ka ʻole o ka lawe ʻana i ka lāʻau lapaʻau), ʻeha ʻeha o ka penis, ʻulaʻula a me ka luku ʻana i ka corpora cavernosa.

Hiki i ka ʻai nui ke mālama i ke kūkulu ʻana a hiki i 6 mau hola. Ma muli o ka hiki ʻana o ka ʻike maka a me ka dizziness ma hope o ka lawe ʻana i ka lāʻau lapaʻau, pono ʻoe e hōʻole i ka hoʻokele kaʻa a me ka hana ʻana me nā mīkini.

6. Nā kumu o ka nawaliwali

Ua wehewehe ʻia ʻo Impotence (ED) ma ke ʻano he "kahi moe kolohe i hōʻike ʻia nele o ke kukulu ana a i ʻole ejaculate ʻoiai ʻo ka hauʻoli a me ka ʻoluʻolu o ka foreplay." ʻO ka impotence ʻaʻole ka nele o kahi kūkulu ʻana i ka wā o ka moe kolohe ʻana, i hele pū ʻia me ke kaumaha.

Hiki iā mākou ke kamaʻilio e pili ana i ka maʻi i ka wā pilikia kūkulu a ʻike pinepine ʻia ka ejaculation, ʻoiai ka pilina ma waena o nā hoa. Hiki ke hoʻokaʻawale ʻia kēia maʻi i ka mua a me ke kula kiʻekiʻe (e loaʻa ana ma hope o ka manawa o ka hana maʻamau).

ʻO ke kumu o nā pilikia i loko o ke ola moe kolohe ʻana hiki ke noʻonoʻo (psychogenic impotence) a me nā mea kūlohelohe (somatic).

Aia ka hui mua: makau i ka moe kolohe, ka makaʻu i ka hāpai ʻana i makemake ʻole ʻia, nā paʻakikī, ka hewa, ka hewa, ke koʻikoʻi, nā maʻi hoʻomohala psychosexual, introversion (ʻano e nānā pono iā ʻoe iho). ʻO ka maʻamau i kēlā mau kūlana, i ka wā hiamoe a i ʻole masturbation, maʻamau nā hopena.

ʻO nā kumu kino o ka maʻi ʻole, ʻo ia nā maʻi (diabetes mellitus, multiple sclerosis, tetraplegia, ALS, nā maʻi puʻuwai, hypertension koʻikoʻi, phimosis, flushing, Peyronie's maʻi) a i ʻole nā ​​loli pili makahiki (andropause) e pale ai i ke kūkulu ʻana. Hiki i kekahi mau mea hoʻoikaika kino (ka waiʻona, amphetamines) a me nā lāʻau lapaʻau (SSRIs, SNRIs) ke kumu i ka maʻi ʻole.

E hauʻoli i nā lawelawe lapaʻau me ka laina ʻole. E hoʻopaʻa manawa me kahi loea me ka e-prescription a me ka e-certificate a i ʻole kahi hoʻokolokolo ma abcHealth E ʻimi i ke kauka.